(S, R, S) -AHPC-Me
(S, R, S) -AHPC-Me is a potent VHL ligand derived from (S, R, S) -AHPC, designed for targeted protein degradation. It effectively degrades BET proteins with a DC50 below 1 nM in resistant prostate cancer cell models and serves as a key component in the synthesis of the PROTAC degrader ARV-771 for cancer research.
Product Specifications
CAS Number
1948273-02-6
Product Name Alternative
(S, R, S) AHPCMe, (S, R, S) AHPC Me, AHPC-Me, E3 ligase Ligand 1A, Ligands for E3 Ligase, Ligand for E3 Ligase, LigandforE3Ligase, inhibit, E3 ligase-recruiting Moiety, Inhibitor, VHL ligand 2, VHL ligand2, VHL ligand-2, VHL
Field of Research
Pharmacology & Drug Discovery
Purity
99.86% (May vary between batches)
Smiles
C ([C@H] (C (C) (C) C) N) (=O) N1[C@H] (C (N[C@@H] (C) C2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1
Molecular Formula
C23H32N4O3S
Molecular Weight
444.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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