Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3) is a derivative of thalidomide designed to bind the CRBN E3 ubiquitin ligase. It serves as a key recruiting moiety in PROTACs for targeted protein degradation, a tool widely used in both in vitro biochemical assays and in vivo target validation studies in cancer and disease research.
Product Specifications
CAS Number
1061605-21-7
Product Name Alternative
Thalidomide O COOH, TCE 35031, TCE35031, TCE-35031, ThalidomideOCOOH, Thalidomide-O-COOH, E3 ligase Ligand 3, Cereblon, Cereblon ligand3, Cereblon ligand-3, Cereblon ligand 3, inhibit, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, Inhibitor, E3 ligase-recruiting Moiety
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:42 mg/mL (126.4 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2OCC (O) =O
Molecular Formula
C15H12N2O7
Molecular Weight
332.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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