ADH-503
ADH-503 (GB1275) is an orally active, allosteric agonist of CD11b. It reprograms tumor-associated macrophages, reduces immunosuppressive myeloid cell infiltration, and enhances dendritic cell activity. This small molecule is utilized in immuno-oncology research to study macrophage polarization and antitumor immune responses in both cellular and animal models.
Product Specifications
CAS Number
2055362-74-6
Product Name Alternative
Complement System, ComplementSystem, CD11b, dendritic, ADH503, ADH-503, ADH 503, allosteric, Inhibitor, GB1275, GB-1275, GB 1275, macrophages, orally, inhibit, immunosuppressive, repolarization, tumorassociated, tumor-infiltrating
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
97.03% (May vary between batches)
Solubility
DMSO:5.25 mg/mL (10.01 mM)
Smiles
C[N+] (C) (C) CCO.[O-]C (=O) c1ccc (cc1) -c1ccc (\C=C2/SC (=S) N (Cc3ccccc3) C2=O) o1
Molecular Formula
C27H28N2O5S2
Molecular Weight
524.7
Storage Conditions
-20°C
Notes
For research use only.
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