Afuresertib hydrochloride
Afuresertib hydrochloride is a potent and selective pan-Akt kinase inhibitor, exhibiting Kis of 0.08, 2, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. It is widely used in preclinical research to investigate the PI3K/Akt signaling pathway in cancer, with applications in both in vitro cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
1047645-82-8
Product Name Alternative
Inhibit, GSK2110183, GSK-2110183, GSK 2110183, Inhibitor, Akt, Afuresertib, Afuresertib Hydrochloride, Afuresertib hydrochloride, Protein kinase C, Protein kinase B, Rho-kinase, Rho-associated kinase, Rho-associated protein kinase, ROK, ROCK, PKB, PKC
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.96% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.62 mM) ; DMSO:100 mg/mL (215.61 mM)
Smiles
Cl.Cn1ncc (Cl) c1-c1cc (sc1Cl) C (=O) N[C@H] (CN) Cc1cccc (F) c1
Molecular Formula
C18H18Cl3FN4OS
Molecular Weight
463.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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