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C25-140

C25-140 is a cell-permeable small molecule that selectively disrupts the TRAF6-Ubc13 protein-protein interaction, inhibiting K63-linked polyubiquitination. It is a valuable research tool for studying NF-κB signaling in inflammation and oncology, with utility in both cellular and animal models.

Product Specifications

CAS Number

1358099-18-9

Product Name Alternative

E3 ligating enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3Enzyme, E1 Enzyme, E1 activating enzyme, C25 140, C25140, C-25-140, C25-140, Inhibitor, NF-κB, NFkB, NFκB, NF-kB, inhibit, TNF Receptor, TNFR, Tumor Necrosis Factor Receptor, TRAF6-Ubc13, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, Ubiquitin ligase

Field of Research

Cell Biology, Protein Biochemistry, Signal Transduction

Purity

98.81% (May vary between batches)

Solubility

DMSO:62.5 mg/mL (136.59 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.37 mM)

Smiles

Cc1nn (c (C) c1CCC (=O) N1CCC (Cc2ccccc2) CC1) -c1ccc2nnc (C) n2n1

Molecular Formula

C26H31N7O

Molecular Weight

457.57

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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