C25-140
C25-140 is a cell-permeable small molecule that selectively disrupts the TRAF6-Ubc13 protein-protein interaction, inhibiting K63-linked polyubiquitination. It is a valuable research tool for studying NF-κB signaling in inflammation and oncology, with utility in both cellular and animal models.
Product Specifications
CAS Number
1358099-18-9
Product Name Alternative
E3 ligating enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3Enzyme, E1 Enzyme, E1 activating enzyme, C25 140, C25140, C-25-140, C25-140, Inhibitor, NF-κB, NFkB, NFκB, NF-kB, inhibit, TNF Receptor, TNFR, Tumor Necrosis Factor Receptor, TRAF6-Ubc13, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, Ubiquitin ligase
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction
Purity
98.81% (May vary between batches)
Solubility
DMSO:62.5 mg/mL (136.59 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.37 mM)
Smiles
Cc1nn (c (C) c1CCC (=O) N1CCC (Cc2ccccc2) CC1) -c1ccc2nnc (C) n2n1
Molecular Formula
C26H31N7O
Molecular Weight
457.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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