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5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime (5'-FIO) is a potent and selective small molecule inhibitor of FLT3 tyrosine kinase, exhibiting an IC50 of 15 nM. It is a valuable research tool for investigating FLT3-driven signaling pathways in acute myeloid leukemia (AML), applicable in both cellular and biochemical assays.

Product Specifications

CAS Number

861214-33-7

Product Name Alternative

RK3E-ras, SNU-638, HT-1080, Inhibitor, Fms like tyrosine kinase 3, FLT3, inhibit, CD135, Cluster of differentiation antigen 135, A549, 5' Fluoroindirubinoxime, 5'-FIO, 5'Fluoroindirubinoxime, 5'-Fluoroindirubinoxime

Field of Research

Cardiovascular Research, Signal Transduction

Purity

95.25% (May vary between batches)

Solubility

DMSO:83.33 mg/mL (282.22 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.18 mM)

Smiles

O\N=C1\C (\Nc2ccccc\12) =C1/C (=O) Nc2ccc (F) cc12

Molecular Formula

C16H10FN3O2

Molecular Weight

295.27

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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