5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime (5'-FIO) is a potent and selective small molecule inhibitor of FLT3 tyrosine kinase, exhibiting an IC50 of 15 nM. It is a valuable research tool for investigating FLT3-driven signaling pathways in acute myeloid leukemia (AML), applicable in both cellular and biochemical assays.
Product Specifications
CAS Number
861214-33-7
Product Name Alternative
RK3E-ras, SNU-638, HT-1080, Inhibitor, Fms like tyrosine kinase 3, FLT3, inhibit, CD135, Cluster of differentiation antigen 135, A549, 5' Fluoroindirubinoxime, 5'-FIO, 5'Fluoroindirubinoxime, 5'-Fluoroindirubinoxime
Field of Research
Cardiovascular Research, Signal Transduction
Purity
95.25% (May vary between batches)
Solubility
DMSO:83.33 mg/mL (282.22 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.18 mM)
Smiles
O\N=C1\C (\Nc2ccccc\12) =C1/C (=O) Nc2ccc (F) cc12
Molecular Formula
C16H10FN3O2
Molecular Weight
295.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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