MRTX849
Adagrasib (MRTX849) is a covalent, orally bioavailable inhibitor that selectively targets the inactive, GDP-bound form of KRAS G12C, blocking its oncogenic signaling. It demonstrates potent anti-tumor activity in both cellular assays and in vivo models, making it a key tool for oncology research targeting KRAS-driven cancers.
Product Specifications
CAS Number
2326521-71-3
Product Name Alternative
Adagrasib
Field of Research
Immunology & Inflammation
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
CN1CCC[C@H]1COc1nc2CN (CCc2c (n1) N1CCN ([C@@H] (CC#N) C1) C (=O) C (F) =C) c1cccc2cccc (Cl) c12
Molecular Formula
C32H35ClFN7O2
Molecular Weight
604.1
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-[ (2S) -4-[7- (8-Chloronaphthalen-1-yl) -2-[[ (2S) -1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1- (2-fluoroprop-2-enoyl) piperazin-2-yl]acetonitrile
Available Sizes
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