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GW779439X

GW779439X is a pyrazolopyridazine inhibitor of Stk1 and Aurora kinase A (AURKA) . It potentiates β-lactam antibiotics against MRSA and MSSA by inducing caspase-3/7-mediated apoptosis, as demonstrated in in vitro studies. This compound is a valuable research tool for investigating bacterial kinase pathways and antibiotic resistance mechanisms.

Product Specifications

CAS Number

551919-98-3

Product Name Alternative

Apoptosis, AuroraKinase, Aurora Kinase, Bacterial, cancer, CDK, derivatives serine, GW779439X, GW-779439X, Inhibitor, lactam, inhibit, kinase, pazolopyridazine, threonine, Stk1, resistant

Field of Research

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology

Purity

97.87% (May vary between batches)

Solubility

DMSO:4.55 mg/mL (10.01 mM)

Smiles

CN1CCN (CC1) c1ccc (Nc2nccc (n2) -c2cnn3ncccc23) cc1C (F) (F) F

Molecular Formula

C22H21F3N8

Molecular Weight

454.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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