GSK046
GSK046 (iBET-BD2) is a selective, orally bioavailable inhibitor targeting the second bromodomain (BD2) of BET proteins, exhibiting potent immunomodulatory activity. It is widely used in research to investigate BET protein function in inflammatory and oncological contexts, with applications in both cellular assays and in vivo models.
Product Specifications
CAS Number
2474876-09-8
Product Name Alternative
GSK046, GSK-046, GSK 046, Epigenetic Reader Domain, EpigeneticReaderDomain, iBET-BD2, Inhibitor, immuno-inflammation, inhibit, BD2, BRD2-BD2, BRD2, BRD3-BD2, BRD3, BRD4, BRDT-BD2, BRDT, BRD4-BD2
Field of Research
Epigenetics & Chromatin
Purity
99.94% (May vary between batches)
Solubility
DMSO:83.33 mg/mL (201.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.96 mM)
Smiles
C[C@H] (Oc1cc (cc (F) c1NC (C) =O) C (=O) N[C@H]1CC[C@H] (O) CC1) c1ccccc1
Molecular Formula
C23H27FN2O4
Molecular Weight
414.47
Storage Conditions
-20°C
Notes
For research use only.
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