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JNJ-63576253 free base

JNJ-63576253 (TRC253) is a potent, orally bioavailable full antagonist of both wild-type and F877L mutant androgen receptor (AR), with IC50 values of 54 nM and 37 nM, respectively, in cellular assays. It is a research compound for studying castration-resistant prostate cancer (CRPC), demonstrating activity in relevant in vivo models.

Product Specifications

CAS Number

2110426-27-0

Field of Research

Metabolism Research

Purity

98.32% (May vary between batches)

Smiles

FC (F) (F) c1cc (cnc1C#N) N1C (=S) N (c2ccc (OC3CCNCC3) nc2) C2 (CCC2) C1=O

Molecular Formula

C23H21F3N6O2S

Molecular Weight

502.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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