API-1
API-1 (NSC-177223) is a selective Akt inhibitor that promotes apoptosis by triggering GSK3β-dependent, β-TrCP/FBXW7-mediated degradation of the anti-apoptotic protein Mcl-1. This mechanism supports its application in cancer research, particularly for studying apoptosis resistance in vitro and evaluating therapeutic potential in vivo.
Product Specifications
CAS Number
36707-00-3
Product Name Alternative
Inhibit, NSC 177223, NSC177223, NSC-177223, Inhibitor, Akt, Akt/PKB inhibitor, Apoptosis, API 1, API1, API-1, Protein kinase B, PKB, TRAIL
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction
Purity
97.15% (May vary between batches)
Solubility
DMSO:22.5 mg/mL (66.71 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM)
Smiles
NC (=O) c1cn ([C@@H]2O[C@H] (CO) [C@@H] (O) [C@H]2O) c2ncnc (N) c2c1=O
Molecular Formula
C13H15N5O6
Molecular Weight
337.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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