KY19382
KY19382 is a potent, orally bioavailable small molecule that dually inhibits the CXXC5-DVL interaction and GSK3β activity (IC50s of 19 and 10 nM), thereby activating Wnt/β-catenin signaling. It has been investigated in preclinical research for metabolic diseases, including studies using high-fat diet-induced in vivo models.
Product Specifications
CAS Number
2226664-93-1
Product Name Alternative
CXXC5-DVL, betacatenin, beta-catenin, bcatenin, A 3051, A3051, A-3051, 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3- (methoxyimino) -2H-indol-2-ylidene]-1,3-dihydro-Ky19382, GSK-3, GSK3, GSK-3β, KY 19382, KY19382, KY-19382, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, Wnt, β-catenin, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
95.02% (May vary between batches)
Solubility
DMSO:5 mg/mL (13.88 mM)
Smiles
CO\N=C1/C (/Nc2ccccc/12) =C1/C (=O) Nc2cc (Cl) c (Cl) cc12
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.19
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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