SQ109

SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for cell killing of 50±8 nM. SQ109, targets MmpL3, is an antitubercular agent.

Product Specifications

CAS Number

[502487-67-4]

Product Name Alternative

NSC 722041

UNSPSC

12352211

Hazard Statement

H302

Target

Antibiotic; Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/SQ109.html

Concentration

10mM

Purity

98.24

Solubility

DMSO : ≥ 25 mg/mL

Smiles

C/C(C)=C/CC/C(C)=C/CNCCNC1[C@H]2C[C@H]3C[C@@H]1C[C@H](C3)C2

Molecular Formula

C22H38N2

Molecular Weight

330.55

Precautions

H302

References & Citations

[1]Veiga-Santos P, et al. SQ109, a new drug lead for Chagas disease. Antimicrob Agents Chemother. 2015 Apr;59 (4) :1950-61.|[2]Jia L, et al. Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug. Br J Pharmacol. 2005 Jan;144 (1) :80-7|[3]Jia L, et al. Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147 (5) :476-85.