GRL-0496
GRL-0496 is a potent small molecule inhibitor of SARS-CoV 3CLpro, demonstrating an IC50 of 30 nM in enzymatic assays and antiviral activity with an EC50 of 6.9 μM in cellular models. It serves as a valuable research tool for studying coronavirus replication and the development of protease-targeted therapeutics in both in vitro and in vivo contexts.
Product Specifications
CAS Number
1087243-14-8
Product Name Alternative
SARS-CoV, SARS-CoV 3CLpro, SARS coronavirus, SARSCoV, inhibit, Inhibitor, GRL0496, GRL-0496, GRL 0496, chloropyridyl, 3CLpro
Field of Research
Infectious Disease & Virology
Purity
>98%
Bioactivity
SARS-CoV-2 chymotrypsin-like protease (3CLpro, Mpro, Nsp5) inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) or Ethanol (up to 25 mg/ml)
Smiles
Clc1cncc (OC (=O) c2cccc3[nH]ccc23) c1
Molecular Formula
C14H9ClN2O2
Molecular Weight
272.7
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
Available Sizes
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