DB2313
DB2313 (Carboximidamide) is a potent and selective small molecule inhibitor of the transcription factor PU.1 (IC50=14 nM), disrupting its binding to DNA. It induces apoptosis in acute myeloid leukemia (AML) cells in vitro and has demonstrated anticancer efficacy in preclinical in vivo models, supporting its use in hematological malignancy research.
Product Specifications
CAS Number
2170606-74-1
Product Name Alternative
DB2313, DB-2313, DB 2313, Carboximidamide, Apoptosis
Field of Research
Cell Biology
Purity
98.63% (May vary between batches)
Solubility
DMSO:3 mg/mL (4.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.41 mM)
Smiles
CC (C) NC (=N) c1ccc2nc ([nH]c2c1) -c1ccc (OCc2cccc (COc3ccc (cc3) -c3nc4ccc (cc4[nH]3) C (=N) NC (C) C) c2F) cc1
Molecular Formula
C42H41FN8O2
Molecular Weight
708.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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