STING agonist-12
Compound 53, an oxindole-based STING agonist, potently activates human STING with an EC50 of 185 nM in both primary and immortalized cells, eliciting a characteristic cytokine profile. This small molecule is a valuable tool for probing STING pathway immunobiology in vitro and has been utilized in preclinical in vivo studies for cancer immunotherapy research.
Product Specifications
CAS Number
2259624-71-8
Product Name Alternative
Inhibitor, MPYS, inhibit, MITA, ERIS, HEK293T, TMEM173, Stimulator of Interferon Genes, STING, STING activator Compound 53, STING agonist 12, STING agonist12, STING agonist-12
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology
Purity
97.69% (May vary between batches)
Solubility
DMSO:60 mg/mL (122.23 mM)
Smiles
CC1 (C) C (=O) N (Cc2c (F) cccc2Cl) c2cc (ccc12) C (=O) NCc1c (F) cc (F) cc1F
Molecular Formula
C25H19ClF4N2O2
Molecular Weight
490.88
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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