NCT-58
NCT-58 is a C-terminal HSP90 inhibitor that suppresses the HER family and Akt phosphorylation without triggering the heat shock response. It demonstrates anti-tumor efficacy by inducing apoptosis in HER2-positive cells and eliminating trastuzumab-resistant breast cancer stem-like cells in vitro.
Product Specifications
CAS Number
2411429-33-7
Product Name Alternative
NCT 58, NCT58, NCT-58, HSP90
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.75% (May vary between batches)
Solubility
DMSO:40 mg/mL (85.73 mM)
Smiles
COc1cc (NC (=O) c2ccc3OC (C) (C) C=Cc3c2OC) ccc1OCCC1CCCCN1
Molecular Formula
C27H34N2O5
Molecular Weight
466.57
Storage Conditions
-20°C
Notes
For research use only.
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