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Seneciphylline

Seneciphylline is a mutagenic and hepatotoxic pyrrolizidine alkaloid, shown to transfer into rat milk. It modulates key hepatic detoxification enzymes, inducing epoxide hydrolase and glutathione-S-transferase while suppressing cytochrome P-450. This compound is used in toxicology research to study metabolic activation, detoxification pathways, and chemical hepatotoxicity in vitro and in vivo.

Product Specifications

CAS Number

480-81-9

Product Name Alternative

Inhibit, Inhibitor, Gutathione S-transferase, GST, GSTs, Glutathione transferases, epoxide, hydrase, CYPs, cytochrome, Cytochrome P450, alkaloid, P-450, P450, pyrrolizidine, Seneciphylline, Toxic

Field of Research

Metabolism Research

Purity

99.53% (May vary between batches)

Solubility

DMSO:3.34 mg/mL (10.02 mM)

Smiles

[H][C@]12CCN3CC=C (COC (=O) [C@] (C) (O) C (=C) C\C (=C\C) C (=O) O1) [C@]23[H]

Molecular Formula

C18H23NO5

Molecular Weight

333.38

Storage Conditions

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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