PF-07284892
PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases the expression of pERK[1][2].
Product Specifications
CAS Number
[2498597-94-5]
Product Name Alternative
ARRY-558
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-07284892.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N[C@H]1C2(CCN(C3=NN=C(SC4=CC=NC(N)=C4Cl)C=N3)CC2)CC5=CC=CC=C51
Molecular Formula
C21H22ClN7S
Molecular Weight
439.96
References & Citations
[1]Abdayem P, et al. Ongoing progress in BRAF-mutated non-small cell lung cancer. Clin Adv Hematol Oncol. 2022 Nov;20 (11) :662-672.|[2]Drilon A, et al. SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov. 2023 Jun 3:OF1-OF13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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