PF-05089771
PF 05089771 is a potent and selective Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 11 nM) that binds to the voltage-sensor domain IV. Its blocking action exhibits a slow, depolarization- and concentration-dependent onset. This compound is a valuable research tool for investigating pain pathways in both in vitro and in vivo models.
Product Specifications
CAS Number
1235403-62-9
Product Name Alternative
PF771
Field of Research
Neuroscience
Purity
>98%
Bioactivity
Nav1.7 inhibitor (selective)
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
Nc1n[nH]cc1-c1cc (Cl) ccc1Oc1cc (F) c (cc1Cl) S (=O) (=O) Nc1cscn1
Molecular Formula
C18H12Cl2FN5O3S2
Molecular Weight
500.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[2- (5-Amino-1H-pyrazol-4-yl) -4-chlorophenoxy]-5-chloro-2-fluoro-N- (1,3-thiazol-4-yl) benzenesulfonamide
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