6-Aminonicotinamide
6-Aminonicotinamide (6-AN) is a potent inhibitor of NADP+-dependent enzymes, notably 6-phosphogluconate dehydrogenase. It is widely used in research to model the pentose phosphate pathway inhibition in studies of cancer metabolism, neurodegeneration, and ischemic injury, both in vitro and in vivo.
Product Specifications
CAS Number
329-89-5
Product Name Alternative
Redox, reactions, Inhibitor, inhibit, nicotinamide, NADP+-dependent enzyme, 6Aminonicotinamide, 6-Aminonicotinamide, 6 Aminonicotinamide, ATP, antimetabolite, depletion, DNA-crosslinking
Field of Research
Metabolism Research
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.58 mM) ; DMSO:27.5 mg/mL (200.53 mM)
Smiles
NC (=O) C1=CN=C (N) C=C1
Molecular Formula
C6H7N3O
Molecular Weight
137.14
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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