Voxelotor
Voxelotor (GBT 440) is a small molecule therapeutic agent for sickle cell disease research that inhibits hemoglobin S polymerization by covalently binding to the alpha chain. It functions as a hemoglobin stabilizer and a cytochrome P450 3A4 inhibitor, with applications in both in vitro mechanistic studies and in vivo preclinical models.
Product Specifications
CAS Number
1446321-46-5
Product Name Alternative
Polymerization, inhibit, GBT 440, GBT440, GBT-440, Inhibitor, HbS, haemoglobin, disease, cell, sickle, sickle hemoglobin (HbS), SCD, voxelotor
Field of Research
Pharmacology & Drug Discovery
Purity
99.87% (May vary between batches)
Solubility
DMSO:79 mg/mL (234.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM)
Smiles
CC (C) n1nccc1-c1ncccc1COc1cccc (O) c1C=O
Molecular Formula
C19H19N3O3
Molecular Weight
337.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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