[D-Trp7,9,10]-Substance P

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

Product Specifications

CAS Number

[89430-38-6]

UNSPSC

12352209

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/d-trp7-9-10-substance-p.html

Solubility

10 mM in DMSO

Smiles

C([C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@@H](CCSC)C(N)=O)=O)=O)NC([C@@H](NC([C@@H](CC=3C=4C(NC3)=CC=CC4)NC([C@@H](NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(=O)[C@H]6N(C([C@H](CCCNC(=N)N)N)=O)CCC6)CCCCN)=O)CCC5)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC7=CC=CC=C7)=O)C=8C=9C(NC8)=CC=CC9

Molecular Formula

C79H105N21O13S

Molecular Weight

1588.88

References & Citations

[1]Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114 (1) :101-104.|[2]Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267 (23) :16237-16243.