Sodium Salicylate

Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle[4].

Product Specifications

CAS Number

[54-21-7]

Product Name Alternative

Salicylic acid (sodium salt) ; 2-Hydroxybenzoic acid (sodium salt)

UNSPSC

12352005

Hazard Statement

H302, H319, H361, H402

Target

Apoptosis; Autophagy; COX; Endogenous Metabolite; NF-κB; Ribosomal S6 Kinase (RSK)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Sodium-Salicylate.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(O[Na])C1=CC=CC=C1O

Molecular Formula

C7H5NaO3

Molecular Weight

160.10

Precautions

H302, H319, H361, H402

References & Citations

[1]Mitchell JA, et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51 (6) :907-12.|[2]Nixon M, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012 Apr;61 (4) :790-6.|[3]Dongmei Bai, et al. Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation. Cancer Lett. 2020 Oct 8; S0304-3835 (20) 30506-1.|[4]Juhyun Oh, et al. Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY) . 2016 Nov; 8 (11) : 2871–2884.