USP10-IN-3

USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase[1].

Product Specifications

CAS Number

[3059565-11-3]

UNSPSC

12352005

Target

Apoptosis; Deubiquitinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/usp10-in-3.html

Purity

98.00

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

CC1=CC=C2C(C(C3=NC(C4=C(C=CC=C4)C)=NO3)=CN(C2=C1)CC(NCCC5=CC=C(C=C5)Cl)=O)=O

Molecular Formula

C29H25ClN4O3

Molecular Weight

512.99

References & Citations

[1]Lu Y, et al. Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression. Eur J Med Chem. 2024 Jun 5;272:116468.