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AMG 837 calcium hydrate

AMG 837 calcium hydrate is a potent and selective GPR40 agonist (EC50 = 13 nM), exhibiting over 1000-fold selectivity against related receptors GPR41, GPR43, and GPR120. This small molecule is a valuable research tool for investigating GPR40's role in glucose homeostasis and insulin secretion in both cellular and animal models of diabetes.

Product Specifications

CAS Number

1259389-38-2

Product Name Alternative

AMG 837 calcium, AMG 837 calcium Hydrate, AMG 837 calcium hydrate, Inhibitor, insulin, GPR40, glucose, FFAR, FFA1, Free Fatty Acid Receptor, inhibit

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

98.07% (May vary between batches)

Solubility

DMSO:40 mg/mL (42.06 mM)

Smiles

[H]O[H].[H]O[H].O=C ([O-]) C[C@H] (C#CC) C1=CC=C (OCC2=CC (C3=CC=C (C (F) (F) F) C=C3) =CC=C2) C=C1.O=C ([O-]) C[C@H] (C#CC) C4=CC=C (OCC5=CC (C6=CC=C (C (F) (F) F) C=C6) =CC=C5) C=C4.[Ca+2]

Molecular Formula

C52H44CaF6O8

Molecular Weight

950.97

Storage Conditions

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

Available Sizes

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