Abrocitinib
Abrocitinib (PF-04965842) is a potent and selective oral inhibitor of JAK1, demonstrating high selectivity over JAK2 (IC50s: 29 nM and 803 nM, respectively) . It is a valuable research tool for investigating JAK1-mediated pathways in immunological and inflammatory diseases, with utility in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
1622902-68-4
Product Name Alternative
PF04965842, PF-04965842, PF 04965842, inhibit, JAK1, JAK2, JAK, Janus kinase, Inhibitor, Abrocitinib
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.05% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.37 mM) ; DMSO:125 mg/mL (386.51 mM)
Smiles
CCCS (=O) (=O) N[C@H]1C[C@H] (C1) N (C) c1ncnc2[nH]ccc12
Molecular Formula
C14H21N5O2S
Molecular Weight
323.41
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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