AMG-3969
AMG-3969 is a potent small molecule disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) interaction, exhibiting an IC50 of 4 nM. This tool compound is valuable for diabetes research, enabling the study of hepatic glucose metabolism in both cellular and animal models to explore potential therapeutic strategies.
Product Specifications
CAS Number
1361224-53-4
Product Name Alternative
Glucokinase, GK-GKRP, Hexokinase D, Hexokinase IV, Inhibitor, inhibit, AMG 3969, AMG3969, AMG-3969
Field of Research
Metabolism Research
Purity
98.89% (May vary between batches)
Solubility
DMSO:100 mg/mL (191.4 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.66 mM)
Smiles
CC#C[C@H]1CN (CCN1c1ccc (cc1) C (O) (C (F) (F) F) C (F) (F) F) S (=O) (=O) c1ccc (N) nc1
Molecular Formula
C21H20F6N4O3S
Molecular Weight
522.46
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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