MI-463
MI-463 is a potent, orally bioavailable small molecule inhibitor of the menin-MLL protein-protein interaction, exhibiting an IC50 of 15.3 nM. It is a valuable chemical probe for researching MLL-rearranged leukemias in both cellular assays and in vivo models.
Product Specifications
CAS Number
1628317-18-9
Product Name Alternative
Inhibitor, Menin-MLL, Histone Methyltransferase, HistoneMethyltransferase, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit, MI 463, MI463, MI-463
Field of Research
Epigenetics & Chromatin
Purity
99.18% (May vary between batches)
Solubility
DMSO:120 mg/mL (247.66 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.26 mM)
Smiles
Cc1c (CN2CCC (CC2) Nc2ncnc3sc (CC (F) (F) F) cc23) ccc2[nH]c (cc12) C#N
Molecular Formula
C24H23F3N6S
Molecular Weight
484.54
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
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