GSK484 hydrochloride
GSK484 hydrochloride is a potent, reversible PAD4 inhibitor with IC50 values of 50 nM (without Ca2+) and 250 nM (with 2 mM Ca2+) . It has been shown to enhance the radiosensitivity of colorectal cancer cells and to suppress neutrophil extracellular trap (NET) formation in both cellular and animal studies.
Product Specifications
CAS Number
1652591-81-5
Product Name Alternative
Field of Research
Epigenetics & Chromatin
Purity
98.32% (May vary between batches)
Solubility
PBS:<1 mg/mL (insoluble or slightly soluble) ; DMSO:247.5 mg/mL (485.27 mM) ; H2O:100 mg/mL (196.07 mM)
Smiles
Cl.COc1cc (cc2nc (-c3cc4ccccc4n3CC3CC3) n (C) c12) C (=O) N1CC[C@@H] (O) [C@@H] (N) C1
Molecular Formula
C27H32ClN5O3
Molecular Weight
510.03
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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