LY 3000328
LY 3000328 is a potent and selective cathepsin S inhibitor, with IC50 values of 7.7 nM (human) and 1.67 nM (mouse) . It is a research tool for studying extracellular matrix remodeling, with applications in investigating abdominal aortic aneurysm (AAA) progression in preclinical models through the inhibition of elastin and collagen degradation.
Product Specifications
CAS Number
1373215-15-6
Product Name Alternative
Cathepsin, Cathepsin S, Cathepsin S inhibitor, CysteineProtease, Cysteine Protease, inhibit, LY 3000328, LY3000328, LY-3000328, Inhibitor
Field of Research
Protein Biochemistry
Purity
97.83% (May vary between batches)
Solubility
DMSO:62.5 mg/mL (128.99 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.13 mM)
Smiles
CNC (=O) O[C@H]1COc2ccc (cc2[C@@H]1NC (=O) c1ccc (F) cc1) N1CCN (CC1) C1COC1
Molecular Formula
C25H29FN4O5
Molecular Weight
484.52
Storage Conditions
Store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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