VH-298
VH-298 is a cell-permeable small molecule that potently inhibits the VHL-HIF-α interaction, stabilizing HIF-α and inducing a hypoxic response independent of PHD enzyme inhibition. It is a valuable chemical probe for studying hypoxia signaling pathways and has demonstrated utility in both cellular assays and in vivo models for angiogenesis and ischemia research.
Product Specifications
CAS Number
2097381-85-4
Product Name Alternative
VH298, VH-298, VH 298, VHL, E3 ligase-recruiting Moiety, HIF-1α, Inhibitor, inhibit, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery
Purity
99.06% (May vary between batches)
Solubility
DMSO:78.3 mg/mL (149.53 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.82 mM)
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) C2 (CC2) C#N) C (C) (C) C) cc1
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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