Navtemadlin
Navtemadlin (AMG-232) is a highly potent and selective oral inhibitor of the p53-MDM2 interaction, exhibiting an IC50 of 0.6 nM and a Kd of 0.045 nM for MDM2. It is widely used in cancer research to reactivate p53 pathways, demonstrating antitumor efficacy in both in vitro cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
1352066-68-2
Product Name Alternative
Field of Research
Cell Biology, Protein Biochemistry
Purity
95.55% (May vary between batches)
Solubility
DMSO:150 mg/mL (263.83 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.52 mM) ; H2O:Insoluble
Smiles
CC (C) [C@@H] (CS (=O) (=O) C (C) C) N1[C@@H] ([C@H] (C[C@] (C) (CC (O) =O) C1=O) c1cccc (Cl) c1) c1ccc (Cl) cc1
Molecular Formula
C28H35Cl2NO5S
Molecular Weight
568.55
Storage Conditions
Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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