K145 hydrochloride
K145 hydrochloride is an orally active, substrate-competitive, and selective SphK2 inhibitor (IC50 = 4.3 μM, Ki = 6.4 μM) . It exhibits potent antitumor activity by inducing apoptosis, making it a valuable tool for oncology research in both cellular and animal models of cancer.
Product Specifications
CAS Number
1449240-68-9
Product Name Alternative
Antitumor, anti-proliferative, Apoptosis, apoptotic, Akt, ERK, Inhibitor, oral, K 145, K 145 Hydrochloride, K145, K-145, K145 hydrochloride, K145 Hydrochloride, K-145 Hydrochloride, K-145 hydrochloride, inhibit, SphK2, SphK, sphingosine, Sphingosine kinase, S1PReceptor, substrate-competitive, S1P Receptor, S1P
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.09% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.6 mM) ; H2O:125 mg/mL (324.74 mM) ; DMSO:45 mg/mL (116.91 mM)
Smiles
Cl.CCCCOc1ccc (CC\C=C2/SC (=O) N (CCN) C2=O) cc1
Molecular Formula
C18H25ClN2O3S
Molecular Weight
384.92
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
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