Resatorvid
Resatorvid (TAK-242) is a selective TLR4 inhibitor that covalently binds to Cys747, disrupting TIRAP recruitment and downstream signaling. This small molecule is widely used in research for its demonstrated anti-inflammatory, neuroprotective, and antitumor effects in both cellular and animal models of sepsis, neuroinflammation, and cancer.
Product Specifications
CAS Number
243984-11-4
Product Name Alternative
TLR, TLR4, TNF Receptor, TNF-R, TNFR, TAK242, TAK-242, TAK 242, Resatorvid, Toll-like Receptor (TLR), Tumor Necrosis Factor Receptor, TRIF, Interleukin Related, Interleukin, Inhibitor, inhibit, MyD88, inflammatory, IL-6, Autophagy, CLI-095, CLI095, CLI 095, diseases
Field of Research
Cell Biology, Immunology & Inflammation
Purity
99.31% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.82 mM) ; DMSO:255 mg/mL (704.77 mM)
Smiles
CCOC (=O) C1=CCCC[C@H]1S (=O) (=O) Nc1ccc (F) cc1Cl
Molecular Formula
C15H17ClFNO4S
Molecular Weight
361.82
Storage Conditions
Keep away from direct sunlight, store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
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