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Resatorvid

Resatorvid (TAK-242) is a selective TLR4 inhibitor that covalently binds to Cys747, disrupting TIRAP recruitment and downstream signaling. This small molecule is widely used in research for its demonstrated anti-inflammatory, neuroprotective, and antitumor effects in both cellular and animal models of sepsis, neuroinflammation, and cancer.

Product Specifications

CAS Number

243984-11-4

Product Name Alternative

TLR, TLR4, TNF Receptor, TNF-R, TNFR, TAK242, TAK-242, TAK 242, Resatorvid, Toll-like Receptor (TLR), Tumor Necrosis Factor Receptor, TRIF, Interleukin Related, Interleukin, Inhibitor, inhibit, MyD88, inflammatory, IL-6, Autophagy, CLI-095, CLI095, CLI 095, diseases

Field of Research

Cell Biology, Immunology & Inflammation

Purity

99.31% (May vary between batches)

Solubility

H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.82 mM) ; DMSO:255 mg/mL (704.77 mM)

Smiles

CCOC (=O) C1=CCCC[C@H]1S (=O) (=O) Nc1ccc (F) cc1Cl

Molecular Formula

C15H17ClFNO4S

Molecular Weight

361.82

Storage Conditions

Keep away from direct sunlight, store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

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