Sorafenib N-oxide

Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201) . Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM[1][2].

Product Specifications

CAS Number

[583840-03-3]

UNSPSC

12352005

Hazard Statement

H360, H362, H372, H410

Target

Cytochrome P450; Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sorafenib-n-oxide.html

Purity

99.7

Smiles

O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=[N+]1[O-])NC

Molecular Formula

C21H16ClF3N4O4

Molecular Weight

480.82

Precautions

H360, H362, H372, H410

References & Citations

[1]Li L, et al. Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 1;878 (29) :3033-8. |[2]Ghassabian S, et al. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4. AAPS J. 2019 Jan 9;21 (2) :15.