Recombinant Human Lymphotoxin-alpha protein (LTA) (Active)

Product Specifications

Background

Cytokine that in its homotrimeric form binds to TNFRSF1A, TNFR1, TNFRSF1B, TNFBR and TNFRSF14, HVEM. In its heterotrimeric form with LTB binds to TNFRSF3, LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Product Name Alternative

LT-alpha, Tumor necrosis factor ligand superfamily member 1

Gene ID

4049

UniProt

P01374

Target

LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L

Purification

>96% as determined by SDS-PAGE and HPLC.

Bioactivity

Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg, ml, corresponding to a specific activity of 2.0 108 IU, mg in the presence of actinomycin D.

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.