SP-146
SP-146 is a highly selective and potent Aurora B kinase inhibitor with a sub-nanomolar IC50 of 0.316 nM, operating via a non-ATP-competitive mechanism. It is a valuable chemical probe for studying mitosis and has been utilized in both in vitro biochemical assays and in vivo cancer research models to investigate cell cycle regulation and antitumor activity.
Product Specifications
Product Name Alternative
Aurora B, Aurora Kinase, AuroraKinase, SP 146, SP146, SP-146
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
97.82% (May vary between batches)
Solubility
DMSO:91 mg/mL (200.67 mM)
Smiles
Cn1cc (cn1) c2ccc5c (c2) ncnc5Nc4cccc (NC (=O) Nc3cccc (F) c3) c4
Molecular Formula
C25H20FN7O
Molecular Weight
453.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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