PF-05186462
PF-05186462 is a potent and state-dependent small molecule inhibitor that selectively targets the Nav1.7 voltage-gated sodium channel with an IC50 of 21 nM, while showing minimal activity against Nav1.5. This selectivity makes it a valuable research tool for investigating pain pathways in both in vitro electrophysiology studies and in vivo models of nociception.
Product Specifications
CAS Number
1235406-03-7
Product Name Alternative
Channel, chronic, acute, Inhibitor, inhibit, Na+ channels, Na channels, Nav1.7 channel, Nav1.7, pain, PF 05150122, PF 05186462, PF05186462, PF-05186462, PF05150122, PF-05150122, Sodium Channel, sodium, SodiumChannel, voltage
Field of Research
Pharmacology & Drug Discovery
Purity
99.10% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM) ; DMSO:11 mg/mL (20.68 mM)
Smiles
O (C1=C (C=C (C (F) (F) F) C=C1) C=2C=CN=NC2) C3=C (Cl) C=C (S (NC4=NN=CS4) (=O) =O) C (F) =C3
Molecular Formula
C19H10ClF4N5O3S2
Molecular Weight
531.89
Storage Conditions
-20°C
Notes
For research use only.
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