Compound 23
This compound, known as PROTAC BRAF-V600E degrader-1, is a selective small molecule that targets the oncogenic BRAF-V600E mutant protein for degradation while sparing the wild-type BRAF protein. It serves as a valuable chemical tool for investigating targeted protein degradation in cancers harboring the V600E mutation, applicable in both cellular and in vivo preclinical research models.
Product Specifications
CAS Number
2417296-84-3
Product Name Alternative
Compound 23, A375, BRAF-V600E, B-Raf (V600E), anticancer, Inhibitor, inhibit, melanoma, HT-29, Raf, Raf kinases, PROTAC BRAF-V600E degrader-1, PROTACs, ubiquitin-proteasome system
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.43% (May vary between batches)
Solubility
DMSO:10 mM
Smiles
FC1=C (N2C=3C (C (=C2) C=4C=NC=NC4) =NC (N (C) C5CCN (C (CCOCCOCCOCCNC6=C7C (C (=O) N (C7=O) C8C (=O) NC (=O) CC8) =CC=C6) =O) CC5) =CC3) C (F) =CC=C1NS (CCC) (=O) =O
Molecular Formula
C48H54F2N10O10S
Molecular Weight
1001.07
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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