KRAS inhibitor-9
KRAS inhibitor-9 (DUN09716) is a selective, mutation-targeting small molecule that binds KRAS with a Kd of 92 μM, inhibiting GTP-KRAS formation and downstream signaling. This activity leads to G2/M arrest and apoptosis in KRAS-mutant NSCLC cells, making it a valuable tool for in vitro studies of oncogenic KRAS biology and targeted therapy mechanisms.
Product Specifications
CAS Number
300809-71-6
Product Name Alternative
H358, H460, H2122, GTP-KRAS, Inhibitor, lung, mutant, inhibit, KRAS, KRAS inhibitor 9, KRAS inhibitor9, KRAS inhibitor-9, non-small, cytotoxicity, DUN09716, DUN-09716, DUN 09716, cells, cell, cancer, Apoptosis, Ras, proliferation
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.66% (May vary between batches)
Solubility
DMSO:230 mg/mL (785.49 mM)
Smiles
Nc1ccc (Sc2nc3ccccc3s2) c (Cl) c1
Molecular Formula
C13H9ClN2S2
Molecular Weight
292.81
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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