TYK2-IN-12

TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research[1].

Product Specifications

CAS Number

[2244061-66-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

IFNAR; JAK

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tyk2-in-12.html

Purity

98.81

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=CC(F)=C1C2=NC(CN3)=C(C(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C2)C3=O

Molecular Formula

C24H20F2N4O2

Molecular Weight

434.44

Precautions

H302, H315, H319

References & Citations

[1]Leit S, et al. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett. 2022 Jul 13;73:128891.