CAN508
CAN508 is a potent and selective ATP-competitive inhibitor of CDK9/cyclin T1 (IC50=0.35 μM), showing 38-fold selectivity over other CDKs like CDK2/cyclin E. Its mechanism supports its investigation as a potential antitumor agent in cancer research, applicable for both in vitro biochemical assays and cellular studies.
Product Specifications
CAS Number
140651-18-9
Product Name Alternative
ATP-competitive, CAN 508, CAN508, CAN-508, adenocarcinoma, Cyclin dependent kinase, cells, CDK9/cyclin T1, CDK, inhibit, Inhibitor, HT-29, esophageal
Field of Research
Cell Biology
Purity
98.65% (May vary between batches)
Solubility
DMSO:250 mg/mL (1145.63 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (22.91 mM)
Smiles
Nc1n[nH]c (N) c1\N=N\c1ccc (O) cc1
Molecular Formula
C9H10N6O
Molecular Weight
218.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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