(E/Z) -IT-603
(E/Z) -IT-603 is a cell-permeable small molecule that acts as a direct and reversible c-Rel inhibitor with an IC50 of 3 μM. It disrupts c-Rel's DNA binding and transcriptional activity by inducing a conformational change. This inhibitor is a valuable tool for studying NF-κB signaling in immunological and oncological research, applicable in both cellular and animal models.
Product Specifications
CAS Number
292168-90-2
Product Name Alternative
C-Rel, disease, (E/Z) IT 603, (E/Z) -IT 603, (E/Z) IT603, (E/Z) -IT603, (E/Z) -IT-603, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NF-kB, NFkB, immunomodulatory, IT603, IT-603, IT 603, inhibit, Inhibitor, GVHD, therapy
Field of Research
Signal Transduction
Purity
98.97% (May vary between batches)
Solubility
DMSO:27.5 mg/mL (83.54 mM)
Smiles
COc1cc (Br) cc (\C=C2\NC (=S) NC2=O) c1O
Molecular Formula
C11H9BrN2O3S
Molecular Weight
329.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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