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TC-G 1005

TC-G 1005 is a highly potent and selective GPBA/TGR5 agonist with an EC50 of 0.72 nM, demonstrating oral bioavailability. It shows selectivity over FXR and has been shown in research to elevate plasma GLP-1 and lower blood glucose levels in murine models, supporting its investigation in metabolic disease research.

Product Specifications

CAS Number

1415407-60-1

Product Name Alternative

Inhibitor, levels, G-protein coupled receptor 19, G protein-coupled Bile Acid Receptor 1, glucose, GPBAR1, GPCR19, hTGR5, inhibit, coupled, TC G 1005, TC-G1005, TC-G-1005, TCG 1005, TC-G 1005, Takeda, protein, TGR5

Field of Research

Pharmacology & Drug Discovery

Purity

98.20% (May vary between batches)

Solubility

DMSO:10 mg/mL (25.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.5 mM)

Smiles

Cc1ccc (C) c (Oc2ccncc2C (=O) N2CCN (C3CC3) c3ccccc23) c1

Molecular Formula

C25H25N3O2

Molecular Weight

399.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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