IMT1B
IMT1B (LDC203974) is an orally bioavailable, specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) that suppresses mtDNA transcription, conferring anti-tumor activity. It is used in cancer research to study mitochondrial metabolism and has demonstrated efficacy in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
2304621-06-3
Product Name Alternative
RNASynthesis, RNA Synthesis, RNA, polymerase, oxidative, OXPHOS, POLRMT, phosphorylation, mitochondrial, inhibit, mtDNA, IMT1B, IMT-1B, Inhibitor, LDC 203974, LDC203974, LDC-203974, human, 3-Piperidinecarboxylic acid, 1-[ (2R) -2-[[4- (2-chloro-4-fluorophenyl) -2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S) -, anti-tumour, DNASynthesis, DNA Synthesis, DNA
Field of Research
Cell Biology, Molecular Biology
Purity
95.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.55 mM) ; DMSO:16.9 mg/mL (35.66 mM)
Smiles
C[C@@H] (Oc1ccc2c (cc (=O) oc2c1) -c1ccc (F) cc1Cl) C (=O) N1CCC[C@@H] (C1) C (O) =O
Molecular Formula
C24H21ClFNO6
Molecular Weight
473.88
Storage Conditions
-20°C
Notes
For research use only.
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