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GSK199

GSK199 is a potent and selective inhibitor of peptidyl arginine deiminase 4 (PAD4), exhibiting an IC50 of 200 nM under calcium-free conditions. This small molecule is a valuable research tool for studying PAD4's role in chromatin decondensation, neutrophil extracellular trap (NET) formation, and its implications in autoimmune diseases and cancer in both cellular and animal models.

Product Specifications

CAS Number

1549811-53-1

Product Name Alternative

Inhibitor, GSK 199, GSK199, GSK-199, inhibit, PAD4, Peptidylarginine Deiminase, Protein Arginine Deiminase

Field of Research

Epigenetics & Chromatin

Purity

98.09% (May vary between batches)

Solubility

DMSO:11 mg/mL (23.46 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.13 mM)

Smiles

Cl.CCn1c (cc2cccnc12) -c1nc2cc (cc (OC) c2n1C) C (=O) N1CCC[C@@H] (N) C1

Molecular Formula

C24H29ClN6O2

Molecular Weight

468.98

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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